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2024 05 v.54 858-866
固定化药靶蛋白中药活性成分定向筛选研究进展
基金项目(Foundation): 国家自然科学基金(22374116,22074118)
邮箱(Email): zhaoxf@nwu.edu.cn;
DOI: 10.16152/j.cnki.xdxbzr.2024-05-008
中文作者单位:

西北大学生命科学学院/西部资源生物与现代生物技术教育部重点实验室;

摘要(Abstract):

中药活性成分筛选及作用评价一直是破解药物发现周期长和成功率低等瓶颈问题的核心突破口和重要技术支撑。作者团队创新亲和色谱原理,将药靶蛋白定向固定于色谱担体表面,制备了系列高活性功能化色谱固定相,并提出了固定化药靶蛋白定向筛选中药功效成分的新观点。主要综述了作者团队近五年在固定化药靶蛋白色谱固定相制备技术、中药活性成分定向筛选技术以及活性成分早期成药性评价色谱技术等方面的工作,并对固定化药靶蛋白在中药活性成分定向筛选方面的研究进行了展望。

关键词(KeyWords): 药靶蛋白定向固定;中药活性成分;定向筛选;早期成药性评价
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基本信息:

DOI:10.16152/j.cnki.xdxbzr.2024-05-008

中图分类号:R284.1

引用信息:

[1]寸思迪,张子龙,王云杉等.固定化药靶蛋白中药活性成分定向筛选研究进展[J].西北大学学报(自然科学版),2024,54(05):858-866.DOI:10.16152/j.cnki.xdxbzr.2024-05-008.

基金信息:

国家自然科学基金(22374116,22074118)

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