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2024 05 v.54 840-846
平分型糖链的结构与功能
基金项目(Foundation): 国家自然科学基金(82172828,32071274)
邮箱(Email):
DOI: 10.16152/j.cnki.xdxbzr.2024-05-006
中文作者单位:

西北大学生命科学学院;西北大学医学院;

摘要(Abstract):

平分型N-乙酰氨基葡萄糖GlcNAc(Bisecting N-acetylglucosamine, bisecting GlcNAc)结构是指GlcNAc以β1,4-连接的方式连接到五糖核心的甘露糖(Man)上,是一种特殊的N糖基化修饰。平分型GlcNAc修饰参与多种生物过程,如细胞黏附、受精和胎儿发育、神经发生、免疫反应和肿瘤发展等。主要介绍平分型GlcNAc结构的形成过程,概述平分型GlcNAc修饰在神经系统、免疫反应、肿瘤发展和转移的生物学功能,并总结了解析平分型GlcNAc结构的技术进展,为相应生物学研究及药物开发提供科学参考。

关键词(KeyWords): 平分型N-乙酰氨基葡萄糖;MGAT3;N聚糖;质谱
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基本信息:

DOI:10.16152/j.cnki.xdxbzr.2024-05-006

中图分类号:Q53

引用信息:

[1]关锋,丰晶晶,卫玮等.平分型糖链的结构与功能[J].西北大学学报(自然科学版),2024,54(05):840-846.DOI:10.16152/j.cnki.xdxbzr.2024-05-006.

基金信息:

国家自然科学基金(82172828,32071274)

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