西北大学学报(自然科学版)

目的　为扩大类人胶原蛋白的应用,评定和比较猪胶原蛋白、类人胶原蛋白和明胶在动物体内的生物相容性。方法　分别用胶原材料和明胶进行以下生物学测试:急性毒性试验、溶血试验、热原试验、皮肤刺激试验。根据标准对试验数据进行分析和评估。结果　类人胶原蛋白的急性毒性试验、溶血试验、热原试验、皮肤刺激试验均为阴性。结论　材料生物学测试结果显示类人胶原蛋白较其他两种材料的生物相容性更高,是理想的医用生物材料。

Aim To evaluate compatibility of human-like collagen,collagen and gelatin.Methods Collagen was used to perform the following biological test:acute systematic toxicity test,hemolytic test,pyrogenic reaction test,test for skin irritation.The data was analyzed and evaluated by criterion.Results Human-like collagen presented negative results in those tests.ConclusionResults of material biological evaluation tests show that the biocompatibility of human-like collagen is higher than the other two materials and can therefore serve as an ideal medical material.