| 141 | 9 | 3 |
| 下载次数 | 被引频次 | 阅读次数 |
目的研究有界肿瘤组织中光子分布特性。方法通过建立光在有界肿瘤组织中传输模型,用蒙特卡罗方法模拟光子在有界生物组织的传输,与半无限大肿瘤组织中光子分布的特性对比,分析光子在有界肿瘤组织中的分布特性。结果肿瘤组织中光子能量密度分布在纵向和横向基本是按负指数规律变化,但沿纵向在入射表面附近有极值点,当取定较小边界范围时,光子能量密度增加,组织内的有效光子数下降。结论有界肿瘤组织光子能量密度沿纵向和横向变化规律与半无限大组织变化规律相似,肿瘤组织边界影响光子在生物组织的能量密度和有效光子数分布。
Abstract：Aim To study the character of photons distribution in normal tissue embeded with tumor.Methods A mathematical model based on Monte Carlo method in normal tissue is presented.The light transporting and distribution is simulated in limitary tissue embeded with tumor and compared with semi-infinite tissue.The character of photons distribution was calculated and analyzed.Results The distribution of photons energy vs.depth transforms in terms of minus exponent,but exits extremum near surface.When the tumor dimension is larger,the photon energy density increases and efficient photon numbers decrease.Conclusion The photon energy density vs.depth transforms in limitary tissue is similar to the semi-infinite tissue.The tumor dimension has influence on the distribution of the efficient photon number and energy density.
[1]STEPHEN T F.Montecar lomodelingo flight propagation inhighl yscattering tissue-I:Modelpre-d ictionsandcomparison-w ithd iffusiontheory[J].IEEE Trans B iomed,1989,(36):1 162-1 168.
[2]曹辉,尚志运.液体中光击穿所激发声场的方向性[J].西北大学学报:自然科学版,2003,33(1):19-22.
[3]WANG L H,JACQUES S L,ZHANG L Q.MCML-MonteCarlo modeling of light transport in mu lti-layerd tissues[J].Computer M ethods and Program s in B iom ed ic ine,1995,(47):131-146.
[4]VERKRUYSSE W,PKCKER ING W J,BEEK J F,et al.Modelling the effect ofwavelength on the pu lsed dye lasertreatm ent of port w ine stains[J].App lied Optics,1993,(32):393-398.
[5]裴鹿成,张孝泽.蒙特卡罗方法及其在粒子输运问题中的应用[M].北京:科学出版社,1980.
[6]波恩M,沃耳夫E.光学原理.上册[M].黄乐天,译.北京:科学出版社,1981.
[7]程树英,沈鸿元,陈美锋.用蒙特卡罗法研究折射率对光在组织中的漫反射率和吸收比的影响[J].中国激光,2004,31(2):170-172.
[8]PETERS V G,WYMAN D R,PATTERSON M S,et al.Optical properties of norm al and d iseased hum an breasttissues in the visib le and near infra-red[J].PhysM ed B i-ol,1990,(35):17-34.
[9]李振华,许晓东,贺安之.复杂生物组织中光传输规律的Monte Carlo方法及应用[J].南京理工大学学报,2000,24(6):557-560.
[10]卢毅权,李正佳.光在多层生物组织中传输的蒙特卡罗模拟[J].华中理工大学学报,2000,28(3):102-104.
基本信息:
DOI：
中图分类号:R73-3
引用信息:
[1]阮军,王爽,郝磊等.Monte Carlo方法研究光子在有界肿瘤组织中的分布[J].西北大学学报(自然科学版),2006(06):875-878.
基金信息:
陕西省自然科学基金资助项目(02A08)